KMID : 0939920220540041121
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´ëÇѾÏÇÐȸÁö 2022 Volume.54 No. 4 p.1121 ~ p.1129
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The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)
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Kim Jae-Sik
Kim Kyu-Bo Jung Won-Guen Shin Kyung-Hwan Im Seock-Ah Kim Hee-Jun Kim Yong-Bae Chang Jee-Suk Kim Jee-Hyun Choi Doo-Ho Park Yeon-Hee Kim Dae-Yong Kim Tae-Hyun Choi Byung-Ock Lee Sea-Won Kim Su-Zy Kwon Jeanny Kang Ki-Mun Chung Woong-Ki Kim Kyung-Su Nam Ji-Ho Yoon Won-Sup Kim Jin-Hee Cha Ji-Hye Oh Yoon-Kyeong Kim In-Ah
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Abstract
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Purpose: We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea.
Materials and Methods: We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed (group I [2005?2008], 98 patients; group II [2009?2011], 200 patients; and group III [2012?2014], 302 patients).
Results: Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years; p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p=0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance.
Conclusion: The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.
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KEYWORD
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Brain metastasis, Breast neoplasms, Overall survival, Pattern of care study
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